Bacterial Quorum- sensing Signal Molecules as Potential Inhibitors of Cytokine Storms in COVID-19



Ramakrishnan Sitaraman1, *
1 Department of Biotechnology, TERI School of Advanced Studies, 10 Institutional Area, Vasant Kunj, New Delhi-110070, India


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Creative Commons License
© 2021 Ramakrishnan Sitaraman

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Biotechnology, TERI School of Advanced Studies, 10 Institutional Area, Vasant Kunj, New Delhi, 110070, India; Tel: 91-11-71800222; Fax: 91-11-2612874;
E-mail: minraj@gmail.com


Abstract

In this perspective article, we suggest that bacterial quorum-sensing signal molecules (QSSMs) be systematically screened and evaluated for their ability to exert anti-inflammatory activity in the context of COVID-19-associated cytokine storms and other hyper-inflammatory conditions. Rapid and relevant in vitro screening of these and other compounds (natural or synthetic) can be accomplished by a careful choice of assay systems that are relevant to the disease context. Some lines of evidence indicating the utility of using such an approach, its potential benefits and risks during actual usage, as well as avenues for further research, are discussed.

Keywords: SARS-CoV-2, Inflammation, QSSM, Immunomodulation, Anti-inflammatory, COVID-19, Cytokine release syndrome, Pro-inflammatory.