The Open COVID Journal is an international, peer-reviewed, open-access journal dedicated to publishing innovative and impactful research across all aspects of coronaviruses and COVID-19. In light of the rapid and ongoing scientific advances, the journal has broadened its scope to address emerging areas of significance in coronavirus biology, disease pathogenesis, host response, and public health impact.

We welcome a wide range of contributions, including original research articles, letters, reviews/mini-reviews, case studies, clinical trial reports, and guest-edited thematic issues. The journal is committed to the timely dissemination of high-quality findings that advance our understanding and management of coronavirus-associated diseases.

Scope of the Journal Includes:

• Coronavirus Biology and Evolution

  Origins, genomic diversity, evolution, viral entry mechanisms, replication strategies, and zoonotic spillover dynamics of coronaviruses (SARS-CoV, MERS-CoV, SARS-CoV-2, and related viruses).

  
  
• Host-Virus Interactions

  Innate and adaptive immune responses, cytokine signaling, immune evasion strategies, virus-induced inflammation, and host genetic susceptibility factors.

  
  
• Pathogenesis and Disease Mechanisms

  Multisystem involvement in acute infection, immune dysregulation, vascular and neurological complications, and mechanisms underlying severe disease and mortality.

  
  
• Post-Acute Sequelae (Long COVID)

  Clinical characterization, molecular and immunological underpinnings, impact on quality of life, and strategies for diagnosis and management of long COVID.

  
  
• Therapeutics and Vaccine Development

  Antiviral agents, monoclonal antibodies, immunomodulatory drugs, vaccine design and efficacy, real-world effectiveness, and strategies for next-generation vaccines.

  
  
• Diagnostics and Biomarkers

  Development and validation of molecular, antigen, and serological assays; identification of prognostic and predictive biomarkers for disease progression and recovery.

  
  
• Public Health, Epidemiology, and Policy

  Surveillance, transmission modeling, outbreak response, vaccine coverage, health disparities, pandemic preparedness, and policy responses.

  
  
• Clinical Trials and Translational Studies

  Interventional studies evaluating therapeutic efficacy, vaccine trials, observational cohorts, and translational research bridging bench to bedside.

  
  
• Global Health and Socioeconomic Impacts

  Health system responses, mental health, education, economic recovery, and lessons learned for future pandemic resilience.

  
  

All published content is made freely and globally accessible to support open science and foster collaborative solutions to ongoing and future coronavirus threats.

The Open COVID Journal is an international, peer-reviewed, open-access journal covering all aspects of coronaviruses published continuously by Bentham Open.