REVIEW ARTICLE


A Review Article on Vaccine Development and Therapeutics Approach Against SARS-CoV-2



Ankush Yadav1, Shubhangi Singh1, Vivek Srivastava2, *, Namrata Bardhan1, Saloni Gupta1, Paratpar Sarkar2, Harsimrut Kaur2
1 Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India
2 Department of Chemistry and Biochemistry, School of Basic Sciences and Research, Sharda University, Greater Noida-201308, UP, India


Article Metrics

CrossRef Citations:
0
Total Statistics:

Full-Text HTML Views: 119
Abstract HTML Views: 18
PDF Downloads: 27
Total Views/Downloads: 164
Unique Statistics:

Full-Text HTML Views: 65
Abstract HTML Views: 17
PDF Downloads: 26
Total Views/Downloads: 108



Creative Commons License
© 2021 Yadav et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Chemistry and Biochemistry, School of Basic Sciences and Research, Sharda University, Greater Noida-201308, UP, India; E-mail: vivek.srivastava1@sharda.ac.in


Abstract

In December 2019, a novel coronavirus (COVID-19) unleashed an unprecedented and unanticipated pandemic, causing widespread concern. More than three million deaths have been documented since the first incidence of COVID-19 discovered in China. Several arduous efforts have been made by the governments of various countries worldwide to prevent and control the SARS-CoV-2 infection. This review article discusses an update on all kinds of therapeutic interventions currently applied or developed to treat SARS-CoV-2 condition, including the repurposing of drugs such as Remdesivir, Favipiravir, Ivermectin, etc. We also discuss CRISPR’s potential involvement in antiviral therapy, convalescent plasma therapy, and immunomodulators in combination to tackle the cytokine storms and present a comprehensive overview on many vaccines that have been created to date or are under trials, as well as their platforms and efficacy. Moreover, this article also discusses the mechanism of action of every therapeutic intervention.

Keywords: SARS-CoV-2, CRISPR, Cytokine storm, Hyper inflammation, Immunomodulators, Antiviral.