Translational Structure Map of SARS-CoV-2: A Clinical Analysis of its Origin

Cesar Aguado-Cortes1, Iván Santamaría-Holek1, Victor M. Castaño1, *
1 Universidad Nacional Autónoma de México, Ciudad Universitaria, Cd. de México 04510, Mexico

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© 2023 Aguado- Cortes et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Universidad Nacional Autónoma de México, Ciudad Universitaria, Cd. de México 04510, Mexico E-mail:



SARS-CoV-2 was declared a global health emergency by WHO Emergency Committee based on growing case notification rates at Chinese and international locations. In this paper, we present an approach to understand the probable clinical origin of SARS-CoV-2.


A combination of citation network analysis, analysis of Medical Heading Subject (MeSH) terms, and quantitative content analysis of scientific literature, was employed to map the organization of the clinical origin of SARS-CoV-2 in this paper.


According to the results of the study, a genome of the first 2019-nCoV strain in Hangzhou was obtained, and phylogenetic analysis showed the genome to be closest to the genome of a bat SARS-like coronavirus strain, RaTG13, with an identity of 96.11%.


The studies show that the dead Malayan pangolins found close to the outbreak of COVID-19 in China may have carried coronavirus closely related to SARS-CoV-2.

Keywords: Origin, SARS-CoV-2, Pangolin, Bat, COVID-19 , Pandemic.