RESEARCH ARTICLE
Translational Structure Map of SARS-CoV-2: A Clinical Analysis of its Origin
Cesar Aguado-Cortes1, Iván Santamaría-Holek1, Victor M. Castaño1, *
Article Information
Identifiers and Pagination:
Year: 2023Volume: 3
E-location ID: e266695872305250
Publisher ID: e266695872305250
DOI: 10.2174/26669587-v3-e230711-2022-17
Article History:
Received Date: 09/09/2022Revision Received Date: 15/02/2023
Acceptance Date: 24/02/2023
Electronic publication date: 08/08/2023
Collection year: 2023

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background:
SARS-CoV-2 was declared a global health emergency by WHO Emergency Committee based on growing case notification rates at Chinese and international locations. In this paper, we present an approach to understand the probable clinical origin of SARS-CoV-2.
Methods:
A combination of citation network analysis, analysis of Medical Heading Subject (MeSH) terms, and quantitative content analysis of scientific literature, was employed to map the organization of the clinical origin of SARS-CoV-2 in this paper.
Results:
According to the results of the study, a genome of the first 2019-nCoV strain in Hangzhou was obtained, and phylogenetic analysis showed the genome to be closest to the genome of a bat SARS-like coronavirus strain, RaTG13, with an identity of 96.11%.
Conclusion:
The studies show that the dead Malayan pangolins found close to the outbreak of COVID-19 in China may have carried coronavirus closely related to SARS-CoV-2.